Inflammatory skin conditions—such as atopic dermatitis, psoriasis and rosacea—affect an estimated 20-25% of the global population. As such, there are myriad treatment strategies to prevent inflammatory reactions in the skin; however, some of these methods may actually exacerbate other skin conditions, and should therefore be used with caution. 

Janus Kinase Inhibitors: Function and Unwanted Effects

The management of inflammatory skin conditions is often aided by the use of Janus kinase (JAK) inhibitors, a class of drugs that stop the activity and response of certain JAK enzymes. These enzymes are critical to autoimmune responses by the body, so inhibiting their function prevents messages from cytokines—proteins that stimulate inflammatory reactions in the body.  As a way to calm overactive immune responses, this class of drugs is widely prescribed for patients with chronic inflammatory skin conditions. 

However, a recent review published in the Journal of the American Medical Association of Dermatology shows that the use of JAK inhibitors can significantly increase the likelihood of acne as an unwanted side effect. Out of more than 10,300 subjects, JAK inhibitor use was associated with a 3.83 times higher chance of experiencing a subsequent acne breakout than those patients who were given a placebo. Notably, the use of JAK inhibitors for dermatologic conditions was more strongly associated with the appearance of acne symptoms, as opposed to JAK inhibitors used for non-dermatologic conditions. 

Though the efficacy of JAK inhibitors for certain inflammatory skin conditions is well-supported, patients should be counseled about the significant risk of acne symptoms associated with this treatment protocol. The exact pathophysiology of this reaction requires additional research, particularly when it comes to outcome variances between different JAK inhibitor classes. 

Hyaluronic Acid to Manage Acne Symptoms

Given the extensive use of JAK inhibitors by those with inflammatory skin conditions, and the consequent acne reactions in many patients, effective treatments for acute acne outbreaks are also essential. Hyaluronic acid has become one of the most widely recommended and broadly accepted treatments for chronic skin conditions. Hyaluronic acid (HA) is a natural emollient, found in significant quantities in the body, particularly in the joints, eyes and skin. 

For the treatment of acne, HA's moisturizing qualities help to soothe inflammation and redness by locking moisture into the skin. This can aid in protecting the skin-barrier function by preventing water loss and blocking irritants from the external environment. Additionally, hyaluronic acid can help control sebum production, the excess of which can lead to acne symptoms by clogging your pores. 

Severe acne may also result in scarring, which can negatively affect self-esteem and lead to unfair stigmatization in society. Regular or acute treatment with hyaluronic acid can stimulate the production of collagen, and thus reduce the appearance of acne scarring, along with fine lines, wrinkles and other blemishes. 

A Refreshing Solution from NeuLuna

Whether you're seeking a fast-acting salve for an acne breakout or a comprehensive new approach for overall skin health, the Day and Night Cream from NeuLuna is an ideal choice. This powerful serum benefits from hyaluronic acid as its primary ingredient, supported by a rosehip carrier oil and oleyl erucate for additional skin-smoothing and moisture retention. 

Boasting a patented delivery system that promotes deeper penetration of the functional ingredients, this non-abrasive topical treatment has been carefully engineered for best results. Capable of retaining moisture, relieving redness, soothing irritation and stimulating the production of beneficial compounds, NeuLuna's flagship product delivers on its promises. 

Visit our website for more information on this novel product's design, and take control of your acne symptoms, whether or not they stem from the use of JAK inhibitors!